HDAC6-IN-49


Catalog No. Size PriceQuantity
M34162-C Contact sales@xcessbio.com for quotation $100

Description

HDAC6-IN-49 (Compound 3) is an inhibitor for HDAC with IC50 of 0.012 and 0.735 μM for HDAC6 and HDAC1. HDAC6-IN-49 also exhibits inhibitory activities against MAO-B, cholinesterase (ChE), histamine receptor (H3R) and serotonin 6 receptor (5-HT6R). HDAC6-IN-49 exhibits neuroprotective efficacy on SH-SY5Y cell. HDAC6-IN-49 improves cognitive function and locomotor ability in Drosophila Parkinson's disease models and in C. elegans Alzheimer's disease models.

Product information

Molecular Weight: 457.54

Formula: C23H27N3O5S

Smiles: ONC(=O)C1C=CC(=CC=1)S(=O)(=O)N1C=CC2=CC(=CC=C12)OCCCN1CCCCC1

InChiKey: WKXOTOAMDAIXAM-UHFFFAOYSA-N

InChi: InChI=1S/C23H27N3O5S/c27-23(24-28)18-5-8-21(9-6-18)32(29,30)26-15-11-19-17-20(7-10-22(19)26)31-16-4-14-25-12-2-1-3-13-25/h5-11,15,17,28H,1-4,12-14,16H2,(H,24,27)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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