H2-Gamendazole


Catalog No. Size PriceQuantity
M34676-C Contact sales@xcessbio.com for quotation $100

Description

H2-Gamendazole is a derivative of Lonidamine that reduces cyst formation in polycystic kidney disease and is used in autosomal dominant polycystic kidney disease research.

Product information

CAS Number: 877768-84-8

Molecular Weight: 417.21

Formula: C18H13Cl2F3N2O2

Synonym:

H2-Gamendazole

H2Gamendazole

H2 Gamendazole

Chemical Name: 3-(1-(2,4-dichlorobenzyl)-6-(trifluoromethyl)-1H-indazol-3-yl)propanoic acid

Smiles: OC(=O)CCC1=NN(CC2=CC=C(Cl)C=C2Cl)C2=CC(=CC=C12)C(F)(F)F

InChiKey: OMVYOEVUBVQVKZ-UHFFFAOYSA-N

InChi: InChI=1S/C18H13Cl2F3N2O2/c19-12-3-1-10(14(20)8-12)9-25-16-7-11(18(21,22)23)2-4-13(16)15(24-25)5-6-17(26)27/h1-4,7-8H,5-6,9H2,(H,26,27)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Sundar SV, Zhou JX, Magenheimer BS, Reif GA, Wallace DP, Georg GI, Jakkaraj SR, Tash JS, Yu ASL, Li X, Calvet JP. The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease. Am J Physiol Renal Physiol. 2022 Oct 1;323(4):F492-F506. doi: 10.1152/ajprenal.00095.2022. Epub 2022 Aug 18. PMID: 35979967; PMCID: PMC9529276.

Products are for research use only. Not for human use.

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