TM5441sodium

TM-5441, also known as EBP 883 and BMS-790052, is a potent plasminogen activator inhibitor-1 (PAI-1). TM-5441 inhibits several tumor cell lines with IC50 values between 9.7 and 60.3 μM. TM5441 protects against high-fat diet-induced obesity and adipocyte injury in mice.

Product information

CAS Number: 2319722-53-5

Molecular Weight: 450.80

Formula: C21H16ClN2NaO6

Synonym:

TM5441sodiumTM-5441

Related CAS Number:

1190221-43-2

2319722-53-5

Chemical Name: 5-Chloro-2-[[2-[2-[[3-(3-furanyl)phenyl]amino]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt

Smiles: [Na+].[O-]C(=O)C1=CC(Cl)=CC=C1NC(=O)COCC(=O)NC1=CC(=CC=C1)C1=COC=C1

InChiKey: RDKPAESSEMYFJL-UHFFFAOYSA-M

InChi: InChI=1S/C21H17ClN2O6.Na/c22-15-4-5-18(17(9-15)21(27)28)24-20(26)12-30-11-19(25)23-16-3-1-2-13(8-16)14-6-7-29-10-14;/h1-10H,11-12H2,(H,23,25)(H,24,26)(H,27,28);/q;+1/p-1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Medipally A, Xiao M, Biederman L, Dasgupta A, Satoskar AA, Parikh S, Ivanov I, Mikhalina G, Brodsky SV. Role of plasminogen activated inhibitor-1 in the pathogenesis of anticoagulant related nephropathy. Front Nephrol. 2024 Jun 28;4:1406655. doi: 10.3389/fneph.2024.1406655. PMID: 39006160; PMCID: PMC11239567.
2. Cipolla MJ, Hunt RD, Liebeskind DS, Tremble SM. The impact of collateral therapeutics on stroke hemodynamics in normotensive and hypertensive rats: a step toward translation. Front Neurol. 2024 Mar 21;15:1373445. doi: 10.3389/fneur.2024.1373445. PMID: 38585360; PMCID: PMC10996366.
3. Tanaka K, Harada H, Kamuro H, Sakai H, Yamamoto A, Tomimatsu M, Ikeda A, Chosokabe R, Tanaka S, Okada Y, Fujio Y, Obana M. Arid5a/IL-6/PAI-1 Signaling Is Involved in the Pathogenesis of Lipopolysaccharide-Induced Kidney Injury. Biol Pharm Bull. 2023;46(12):1753-1760. doi: 10.1248/bpb.b23-00482. PMID: 38044094.
4. Palakurti R, Biswas N, Roy S, Gnyawali SC, Sinha M, Singh K, Ghatak S, Sen CK, Khanna S. Inducible miR-1224 silences cerebrovascular Serpine1 and restores blood flow to the stroke-affected site of the brain. Mol Ther Nucleic Acids. 2023 Jan 2;31:276-292. doi: 10.1016/j.omtn.2022.12.019. PMID: 36726407; PMCID: PMC9868883.
5. Shin E, Kang H, Lee H, Lee S, Jeon J, Seong K, Youn H, Youn B. Exosomal Plasminogen Activator Inhibitor-1 Induces Ionizing Radiation-Adaptive Glioblastoma Cachexia. Cells. 2022 Oct 1;11(19):3102. doi: 10.3390/cells11193102. PMID: 36231065; PMCID: PMC9564109.

Products are for research use only. Not for human use.