Description
Phylloflavan is an antileishmanial agent with an intracellular EC50 of 3.2 nM in RAW 264.7 cells. Phylloflavan also inhibits the cytopathic effect of encephalomyocarditis virus on L929 fibroblast cells (38 U/mL).
Product information
CAS Number: 98570-83-3
Molecular Weight: 498.48
Formula: C26H26O10
Synonym:
Phylloflavan
Chemical Name: (2R,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl (S)-5-(3,4-dihydroxyphenyl)-3-hydroxypentanoate
Smiles: O[C@@H](CCC1=CC=C(O)C(O)=C1)CC(=O)O[C@H]1CC2=C(C=C(O)C=C2O)O[C@@H]1C1=CC=C(O)C(O)=C1
InChiKey: FKDRTLFRRHQTGU-TYFWRAIDSA-N
InChi: InChI=1S/C26H26O10/c27-15(4-1-13-2-5-18(29)21(32)7-13)11-25(34)35-24-12-17-20(31)9-16(28)10-23(17)36-26(24)14-3-6-19(30)22(33)8-14/h2-3,5-10,15,24,26-33H,1,4,11-12H2/t15-,24-,26+/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Aloufi BH, Snoussi M, Sulieman AME. Antiviral Efficacy of Selected Natural Phytochemicals against SARS-CoV-2 Spike Glycoprotein Using Structure-Based Drug Designing. Molecules. 2022 Apr 8;27(8):2401. doi: 10.3390/molecules27082401. PMID: 35458599; PMCID: PMC9025634.
- Kolodziej H, Kayser O, Kiderlen AF, Ito H, Hatano T, Yoshida T, Foo LY. Proanthocyanidins and related compounds: antileishmanial activity and modulatory effects on nitric oxide and tumor necrosis factor-alpha-release in the murine macrophage-like cell line RAW 264.7. Biol Pharm Bull. 2001 Sep;24(9):1016-21. doi: 10.1248/bpb.24.1016. PMID: 11558561.
Products are for research use only. Not for human use.
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