Description
Lobeline, CAS No. 90-69-7, also known as C-07475, is a dopamine receptor modulator potentially for the treatment of Tourette's syndrome and attention. Lobeline improves acute lung injury via nuclear factor-κB-signaling pathway and oxidative stress. Lobeline shows protective effects against MPTP-induced dopaminergic neuron death and attenuates behavior deficits in animals.
Product information
CAS Number: 90-69-7
Molecular Weight: 337.46
Formula: C22H27NO2
Chemical Name: 2-((2S, 6R)-6-((S)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethan-1-one
Smiles: CN1[C@H](CC(=O)C2C=CC=CC=2)CCC[C@@H]1C[C@H](O)C1C=CC=CC=1
InChiKey: MXYUKLILVYORSK-HKBOAZHASA-N
InChi: InChI=1S/C22H27NO2/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18/h2-7,9-12,19-21,24H,8,13-16H2,1H3/t19-,20+,21+/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Lobeline (0.1-100 μM) evokes [3H]DA overflow calcium-independently[1]. Lobeline inhibits [3H]DA uptake into synaptosomes (IC50=80 μM) and vesicles (IC50=0.88 μM)[1]. XcessBio has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo:
Lobeline (0.3-3.0 mg/kg; s.c.; single dose) decreases d-methamphetamine self-administration in rats model[3]. Lobeline (3 mg/kg; s.c.; 7 times during 7 sessions) specifically decreases responding for d-methamphetamine in a noncompetitive manner, and increases tolerance development[3]. XcessBio has not independently confirmed the accuracy of these methods. They are for reference only.
Products are for research use only. Not for human use.
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