Description
7-Methylguanosine 5'-diphosphate (7-Methyl-GDP) sodium, a cap analog, can be used in the synthesis of mRNA cap analogues.
Product information
CAS Number: 104809-16-7
Molecular Weight: 479.21
Formula: C11H16N5NaO11P2
Chemical Name: 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-({[hydroxy(sodiooxy)phosphoryl phosphonato]oxy}methyl)oxolan-2-yl]-7-methyl-6-oxo-6,9-dihydro-3H-purin-7-ium
Smiles: C[N+]1=CN([C@@H]2O[C@H](COP([O-])(=O)OP(O)(=O)O[Na])[C@@H](O)[C@H]2O)C2NC(N)=NC(=O)C1=2
InChiKey: GWXMULHRNCYTBF-MCDZGGTQSA-M
InChi: InChI=1S/C11H17N5O11P2.Na/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(26-10)2-25-29(23,24)27-28(20,21)22;/h3-4,6-7,10,17-18H,2H2,1H3,(H5-,12,13,14,19,20,21,22,23,24);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: H2O : 50 mg/mL (104.34 mM; Need ultrasonic and warming).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
7-Methylguanosine 5'-diphosphate sodium inhibits binding of eukaryotic initiation factors to reovirus capped mRNA and complex formation involving uncapped mRNA or 18 S rRNA. T. brucei mRNA decapping enzyme (TbDcp2) that cleaves 7-Methylguanosine 5'-diphosphate sodium from capped RNA to generate pRNA, a substrate for TbCe1.
Products are for research use only. Not for human use.
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