Description
Seletracetam (Ucb 44212) lithium bromide, an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy.
Product information
CAS Number: 2024584-38-9
Molecular Weight: 275.65
Formula: C20H28BrF4LiN4O4
Chemical Name: bis((2S)-2-[(4S)-4-(2,2-difluoroethenyl)-2-oxopyrrolidin-1-yl]butanamide); bromolithium
Smiles: [Li]Br.CC[C@@H](C(N)=O)N1C[C@@H](CC1=O)C=C(F)F.CC[C@@H](C(N)=O)N1C[C@@H](CC1=O)C=C(F)F
InChiKey: QWYBKWYINRAGSI-PVLLDRRKSA-M
InChi: InChI=1S/2C10H14F2N2O2.BrH.Li/c2*1-2-7(10(13)16)14-5-6(3-8(11)12)4-9(14)15;;/h2*3,6-7H,2,4-5H2,1H3,(H2,13,16);1H;/q;;;+1/p-1/t2*6-,7+;;/m11../s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Seletracetam displays one-log-unit higher affinity (pKi=7.1) than Levetiracetam (6.1) to the LEV-binding site. Seletracetam lithium bromide inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro. Seletracetam (1-10 μM) lithium bromide reduces both the amplitude and repetitive firing of population spikes induced by a high K+/low Ca2+ concentration fluid (HKLCF) in rat hippocampal slices.
In Vivo:
Seletracetam (intraperitoneal injection) lithium bromide displays potent protection against secondary generalised motor seizures in fully corneally-kindled mice (ED50 0.31 mg/kg). In audiogenic seizure susceptible mice, Seletracetam (i.p) protects against clonic convulsion expression with an ED50 of 0.17 mg/kg. Seletracetam (0.0074 mg/kg to 74 mg/kg; intraperitoneal injection) lithium bromide increases the generalized seizure threshold current and decreases the duration of the after-discharge and the seizure severity observed at the after-discharge threshold current, and generally has a much more potent effect than previously observed for Levetiracetam.
Products are for research use only. Not for human use.
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