CC-99677


Catalog No. Size PriceQuantity
M34777-C Contact sales@xcessbio.com for quotation $100

Description

CC-99677 is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM). CC-99677 is extracted from patent WO2020236636, compound 1.

Product information

CAS Number: 1887069-10-4

Molecular Weight: 469.94

Formula: C22H20ClN5O3S

Chemical Name: (15R)-5-{[2-chloro-5-(ethoxymethyl)pyrimidin-4-yl]oxy}-15-methyl-11-thia-6,14,17-triazatetracyclo[8.8.0.0²,⁷.0¹²,¹⁸]octadeca-1(10),2,4,6,8,12(18)-hexaen-13-one

Smiles: CCOCC1=CN=C(Cl)N=C1OC1=CC=C2C3=C(C=CC2=N1)SC1=C3NC[C@@H](C)NC1=O

InChiKey: PYOQIOLRFIRRSO-LLVKDONJSA-N

InChi: InChI=1S/C22H20ClN5O3S/c1-3-30-10-12-9-25-22(23)28-21(12)31-16-7-4-13-14(27-16)5-6-15-17(13)18-19(32-15)20(29)26-11(2)8-24-18/h4-7,9,11,24H,3,8,10H2,1-2H3,(H,26,29)/t11-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CC-99677 is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156.3 nM) and cell based assays (EC50=89 nM).

Products are for research use only. Not for human use.

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