Description
APJ receptor agonist 1, a biphenyl acid derivative, is a potent APJ receptor (APJ-R) agonist (EC50s 0.093 and 0.12 nM for human and rat APJ-R, respectively). APJ receptor agonist 1 displays in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 has the potential for the research of heart failure.
Product information
CAS Number: 2287153-38-0
Molecular Weight: 524.01
Formula: C31H26ClN3O3
Chemical Name: 2'-(1H-1,3-benzodiazol-2-yl)-6'-chloro-4-{[(1R)-1-phenylbutyl]carbamoyl}-[1,1'-biphenyl]-2-carboxylic acid
Smiles: CCC[C@@H](NC(=O)C1=CC(C(O)=O)=C(C=C1)C1C(=CC=CC=1Cl)C1NC2=CC=CC=C2N=1)C1C=CC=CC=1
InChiKey: KCWRZNXFHSFVKD-RUZDIDTESA-N
InChi: InChI=1S/C31H26ClN3O3/c1-2-9-25(19-10-4-3-5-11-19)35-30(36)20-16-17-21(23(18-20)31(37)38)28-22(12-8-13-24(28)32)29-33-26-14-6-7-15-27(26)34-29/h3-8,10-18,25H,2,9H2,1H3,(H,33,34)(H,35,36)(H,37,38)/t25-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
The S-atropisomer APJ receptor agonist 1 (compound 15a) is 200-fold more potent than the corresponding R-atropisomer..
In Vivo:
APJ receptor agonist 1 (10-100 μg/min/kg; intravenous infusion) induces a 10% increase in CO with minimal impact on blood pressure (<5% transient blood pressure drop).
Products are for research use only. Not for human use.
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