Description
LB-60-OF61 hydrochloride is a potent NAMPT (nicotinamide phosphoribosyltransferase) inhibitor. LB-60-OF61 hydrochloride is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines.
Product information
CAS Number: 742064-38-6
Molecular Weight: 531.05
Formula: C29H31ClN6O2
Chemical Name: 4-{[2-cyano-7-(2-cyclohexylethyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]methoxy}-N-[(pyridin-3-yl)methyl]benzamide hydrochloride
Smiles: Cl.N#CC1=NC2=C(C=C(COC3C=CC(=CC=3)C(=O)NCC3=CN=CC=C3)N2CCC2CCCCC2)C=N1
InChiKey: JKRUYOPCRGPAMD-UHFFFAOYSA-N
InChi: InChI=1S/C29H30N6O2.ClH/c30-16-27-32-19-24-15-25(35(28(24)34-27)14-12-21-5-2-1-3-6-21)20-37-26-10-8-23(9-11-26)29(36)33-18-22-7-4-13-31-17-22;/h4,7-11,13,15,17,19,21H,1-3,5-6,12,14,18,20H2,(H,33,36);1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
LB-60-OF61 is potent against HCT116 cells with an IC50 around 30?nM as measured in a 384 well format.
Products are for research use only. Not for human use.
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