TAK-683 acetate

TAK-683 acetate is a potent full KISS1 receptor (KISS1R) agonist (IC50=170 pM) with improved metabolic stability. TAK-683 acetate is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC50 values of 0.96 nM and 1.6 nM for human and rat, respectively. TAK-683 acetate depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer.

Product information

Molecular Weight: 1358.50

Formula: C66H87N17O15

Chemical Name: N-{1-[(1-{[({1-[(1-{[1-carbamoyl-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-[(E)-N''-methylcarbamimidamido]butyl)carbamoyl]-3-methylbutyl}carbamoyl)amino]carbamoyl}-2-phenylethyl)carbamoyl]-2-hydroxypropyl}-2-{2-[2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-(1H-indol-3-yl)propanamido}butanediamide; acetic acid

Smiles: CC(C)CC(NC(=O)NNC(=O)C(CC1=CC=CC=C1)NC(=O)C(NC(=O)C(CC(N)=O)NC(=O)C(CC1=CNC2=CC=CC=C12)NC(=O)C(CC1=CC=C(O)C=C1)NC(C)=O)C(C)O)C(=O)NC(CCCN/C(/N)=N/C)C(=O)NC(CC1=CNC2=CC=CC=C12)C(N)=O.CC(O)=O

InChiKey: LLKKPEATBPXPAG-UHFFFAOYSA-N

InChi: InChI=1S/C64H83N17O13.C2H4O2/c1-34(2)26-48(57(88)73-46(20-13-25-69-63(67)68-5)56(87)74-47(55(66)86)29-39-32-70-44-18-11-9-16-42(39)44)78-64(94)81-80-61(92)50(27-37-14-7-6-8-15-37)77-62(93)54(35(3)82)79-60(91)52(31-53(65)85)76-59(90)51(30-40-33-71-45-19-12-10-17-43(40)45)75-58(89)49(72-36(4)83)28-38-21-23-41(84)24-22-38;1-2(3)4/h6-12,14-19,21-24,32-35,46-52,54,70-71,82,84H,13,20,25-31H2,1-5H3,(H2,65,85)(H2,66,86)(H,72,83)(H,73,88)(H,74,87)(H,75,89)(H,76,90)(H,77,93)(H,79,91)(H,80,92)(H3,67,68,69)(H2,78,81,94);1H3,(H,3,4)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 5 mg/mL (3.68 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

TAK-683 acetate exhibits an IC50 value of 150-180 pM and EC50 value of 180 pM in rat KISS1R-expressing Chinese hamster ovary (CHO) cells.

In Vivo:

TAK-683 acetate (subcutaneous injection; 0.008, 0.08, 0.8, or 8 μmol/ml/kg; once daily; 7 days) induces an increase in plasma luteinizing hormone and testosterone levels; however, after day 7, plasma hormone levels and genital organ weights are reduced. TAK-683 acetate (subcutaneous injection; 10, 30, or 100 pmol/h; once daily; 4 weeks) provides a promising for suppressing reproductive functions and hormone-related diseases such as prostate cancer. TAK-683 acetate (subcutaneous injection; 2.1-21 nmol/kg/day; once daily; 12 weeks) has a longer-term evaluation in prostate cancer model, serum concentrations of PSA is reduced in rats, PSA concentrations are reduced to below the limit of detection (0.5 ng/ml)) in all rats by day 14.

Products are for research use only. Not for human use.