Description
AUTAC4 is a mitochondria-targeting autophagy-targeting chimera (AUTAC). AUTAC4 downregulates cytosolic proteins and promotes targeted mitochondrial turnover via mitophagy.
Product information
CAS Number: 2267315-04-6
Molecular Weight: 869.96
Formula: C43H48FN9O8S
Chemical Name: (2R)-3-({2-amino-9-[(4-fluorophenyl)methyl]-6-oxo-6,9-dihydro-1H-purin-8-yl}sulfanyl)-2-acetamido-N-{3-[2-(2-{3-[2-oxo-2-(2-phenyl-1H-indol-3-yl)acetamido]propoxy}ethoxy)ethoxy]propyl}propanamide
Smiles: CC(=O)N[C@@H](CSC1=NC2=C(N=C(N)NC2=O)N1CC1C=CC(F)=CC=1)C(=O)NCCCOCCOCCOCCCNC(=O)C(=O)C1=C(NC2=CC=CC=C21)C1C=CC=CC=1
InChiKey: IYRHHSZRPVKBSQ-XIFFEERXSA-N
InChi: InChI=1S/C43H48FN9O8S/c1-27(54)48-33(26-62-43-50-36-38(51-42(45)52-40(36)57)53(43)25-28-13-15-30(44)16-14-28)39(56)46-17-7-19-59-21-23-61-24-22-60-20-8-18-47-41(58)37(55)34-31-11-5-6-12-32(31)49-35(34)29-9-3-2-4-10-29/h2-6,9-16,33,49H,7-8,17-26H2,1H3,(H,46,56)(H,47,58)(H,48,54)(H3,45,51,52,57)/t33-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 170 mg/mL (195.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
AUTAC4 induces K63-linked polyubiquitination. Accumulation of K63-linked polyubiquitin required approximately 8 h of incubation. AUTAC4 suppresses not only cytochrome c release into the cytosol but also pro-caspase 3 cleavage. The intracellular ATP level after CCCP treatment is also maintained by AUTAC4, suggesting that mitophagy acceleration by AUTAC4 restored energy production by improving mitochondrial quality control. AUTAC4 rescues cells with acute mitochondrial injury by promoting mitophagy. With the use of mito-Rosella, AUTAC4 (10 μM) can induce mitophagy in Detroit 532 cells ~24-72 h after treatment.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.