Description
(R,R)-CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively.
Product information
CAS Number: 1838123-22-0
Molecular Weight: 414.90
Formula: C18H23ClN2O5S
Chemical Name: 1-(4-chloro-2-hydroxy-3-{[(3R)-3-methyloxolan-3-yl]sulfonyl}phenyl)-3-[(1R)-2-methylcyclopent-2-en-1-yl]urea
Smiles: CC1=CCC[C@H]1NC(=O)NC1=CC=C(Cl)C(=C1O)S(=O)(=O)[C@@]1(C)COCC1
InChiKey: DNXKACKCTLURQN-FZKQIMNGSA-N
InChi: InChI=1S/C18H23ClN2O5S/c1-11-4-3-5-13(11)20-17(23)21-14-7-6-12(19)16(15(14)22)27(24,25)18(2)8-9-26-10-18/h4,6-7,13,22H,3,5,8-10H2,1-2H3,(H2,20,21,23)/t13-,18-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 220 mg/mL (530.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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