Description
PFB-FDGlu is a selective lysosomal Glucocerebrosidase (GCase) substrate, which is metabolised by GCase to yield fluorescein. PFB-FDGlu is cell permeable and can be used with a flow cytometer to measure GCase activity in living cells on a single-cell basis.
Product information
CAS Number: 209540-62-5
Molecular Weight: 865.66
Formula: C39H32F5NO16
Chemical Name: 2,3,4,5,6-pentafluoro-N-[3-oxo-3',6'-bis({[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})-3H-spiro[2-benzofuran-1,9'-xanthen]-5-yl]benzamide
Smiles: O[C@H]1[C@@H](O[C@H](CO)[C@@H](O)[C@@H]1O)OC1C=C2OC3C=C(C=CC=3C3(OC(=O)C4=CC(=CC=C34)NC(=O)C3C(F)=C(F)C(F)=C(F)C=3F)C2=CC=1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
InChiKey: YYMJMZGTQFITLS-WXKYVOLFSA-N
InChi: InChI=1S/C39H32F5NO16/c40-24-23(25(41)27(43)28(44)26(24)42)35(54)45-12-1-4-16-15(7-12)36(55)61-39(16)17-5-2-13(56-37-33(52)31(50)29(48)21(10-46)59-37)8-19(17)58-20-9-14(3-6-18(20)39)57-38-34(53)32(51)30(49)22(11-47)60-38/h1-9,21-22,29-34,37-38,46-53H,10-11H2,(H,45,54)/t21-,22-,29-,30-,31+,32+,33-,34-,37-,38-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (115.52 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PFB-FDGlu is cell permeable and can be used with a flow cytometer to measure GCase activity in living cells on a single-cell basis.
Products are for research use only. Not for human use.
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