Spautin-1 --- Autophagy Inhibitor


Catalog No. size PriceQuantity
M60003-2D 10 mM in DMSO (0.738 mL) $79
M60003-2S 2 mg solid $79
M60003-10S 10mg solid $328

Description

Spautin-1 is a novel and potent autophagy inhibitor, which enhances imatinib-induced (MI) apoptosis in chronic myeloid leukemia. Autophagy has been proposed to play a role in MI resistance. Spautin-1 markedly inhibits IM-induced autophagy in CML cells by downregulating Beclin-1. Spautin-1 enhances IM-induced CML cell apoptosis by reducing the expression of the anti-apoptotic proteins Mcl-1 and Bcl-2. Spautin-1 enhances IM-induced apoptosis by inactivating PI3K/AKT and activating downstream GSK3β, leading to downregulation of Mcl-1 and Bcl-2, which represents a promising approach to improve the efficacy of IM in the treatment of patients with CML.

Product information

CAS Number: 1262888-28-7

Molecular Weight: 271.26

Formula: C15H11F2N3

Chemical Name: 6-fluoro-N-(4-fluorobenzyl)quinazolin-4-amine

Smiles: FC1C=CC(CNC2=NC=NC3=CC=C(F)C=C32)=CC=1

InChiKey: AWIVHRPYFSSVOG-UHFFFAOYSA-N

InChi: InChI=1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Spautin-1 was used at 10 µM final concentration in the cellular assays.

In Vivo:

no in vivo use of Spautin-1 was reported so far.

References:

  1. Liu J, et al. Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13. (2011) Cell 147(1), 223-234.
  2. Joseph D. Mancias, et al. Targeting Autophagy Addiction in Cancer. (2011) Oncotarget 2(12):1302-6

Products are for research use only. Not for human use.

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