Thiazovivin is a highly potent, selective, and cell-permeable small molecule Rock inhibitor with effective cellular activity ~ 2 μM. It can enhance survival of human embryonic stem cells (hESCs) or iPSCs after single cell dissociation by trypsin, and dramatically improve the reprogramming efficiency of iPSC (>200 folds) from human fibroblasts when used in combination with SB431542 and PD0325091. It has been shown to exhibit better activity than Y27632 in many stem cell assays.
CAS Number: 1226056-71-8
Molecular Weight: 311.36
Chemical Name: N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 100 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
Thiazovivin is usually used at 0.5-2 μM final concentration in cell culture.
- Lin T, et al. A chemical platform for improved induction of human iPSCs. (2009) Nat. Methods. 6(11), 805-8.
- Xu Y, et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. (2010) Proc. Natl. Acad. Sci. 107, 8129.
Products are for research use only. Not for human use.
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