Thiazovivin, Rock Inhibitor


Catalog No. size PriceQuantity
M60009-2D 10 mM in DMSO (0.643 mL) $79
M60009-2S 2 mg solid $79
M60009-25S 25mg solid $460

Description

Thiazovivin is a selective, cell-permeable small molecule that inhibits ROCK activity at a concentration 2 µM. Thiazovivin improves stemness maintenance of embryo-derived stem-like cells under chemically defined culture conditions in cattle. Thiazovivin directly targets Rho-associated kinase (ROCK) and increases expression of pluripotency factors. The process using thiazovivin could be easier, faster and more cost effective than transgene integration into somatic cells.

Product information

CAS Number: 1226056-71-8

Molecular Weight: 311.36

Formula: C15H13N5OS

Chemical Name: N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide

Smiles: O=C(NCC1C=CC=CC=1)C1=CSC(NC2=CC=NC=N2)=N1

InChiKey: DOBKQCZBPPCLEG-UHFFFAOYSA-N

InChi: InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Thiazovivin is usually used at 0.5-2 μM final concentration in cell culture.

References:

  1. Lin T, et al. A chemical platform for improved induction of human iPSCs. (2009) Nat. Methods. 6(11), 805-8.
  2. Xu Y, et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. (2010) Proc. Natl. Acad. Sci. 107, 8129.

Products are for research use only. Not for human use.

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