XAV939---Wnt Antagonist


Catalog No. size PriceQuantity
M60010-2D 10 mM in DMSO (0.641 mL) $89
M60010-2S 2mg solid $89
M60010-10S 10mg solid $365

Description

Product Information
Molecular Weight: 312.31
Formula: C14H11F3N2OS
Purity: ≥98%
CAS#: 284028-89-3
Solubility: DMSO up to 50 mM
Chemical Name: 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

XAV939 is a potent and selective Wnt pathway antagonist.  It functions to stabilize Axin by inhibiting the poly-ADP-ribosylating enzymes tankyrase 1 and tankyrase 2 with IC50 of 11 nM and 4 nM, respectively.  It has been used to study Wnt-dependent cancers. In addition, XAV939 was shown to stabilize Axin2 level in oligodendrocyte precursor cells in the spinal cord and accelerated their differentiation and myelination after hypoxic and demyelinating injury. It can also robustly induce cardiomyocyte differentiation from mouse and human ESCs/iPSCs.

 

How to Use: 

 

 

  • In vitro:  XAV939 was used at 1 µM concentration to stabilize Axin and in stem cell culture. It can be used to functionally replace Dkk protein in blocking Wnt signaling in many assay conditions (e.g., 40 times more effective in inducing cardiogenesis than recombinant Wnt inhibitor protein Dkk).
  • In vivo: n/a
  1. 1.  Huang SMA, et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling; (2009) Nature. 461, 614-620

 

 

 

Reference:

  1. Wang H, et al. Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling. (2011) ACS Chem Biol. 6(2):192-7.

  2. Fancy SP, et al. Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.  (2011) Nat Neurosci. 14(8):1009-16.

  3. Willems E, et al. Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm.  (2011) Circ Res.109(4):360-4.


 

 


Products are for research use only. Not for human use.

Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed