Y-27632 --- Rock Inhibitor.

Catalog No. size PriceQuantity
M60011-2S 2mg solid $79
M60011-10S 10mg solid $320


Y-27632 is a widely used, selective inhibitor of the Rho-associated protein kinase p160ROCK with a Ki value at ~ 0.14 μM. In many studies, it was shown and used to enhance the survival and cloning efficiency of many primary cell types after single cell dissociation without affecting their self-renewal properties, including hESC/iPSCs, neural stem cells, intestinal stem cells, and mammary epithelial cells.

Product information

CAS Number: 146986-50-7

Molecular Weight: 247.34

Formula: C14H21N3O

Chemical Name: (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide

Smiles: C[C@@H](N)[C@@H]1CC[C@H](CC1)C(=O)NC1C=CN=CC=1


InChi: InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Y-27632 is typically used at 10 μM concentration in cell culture.

In Vivo:

In several hypertension rat models, Y-27632 was orally dosed at 30 mg/kg to significantly decrease blood pressure.


  1. Uehata M, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension.(1997) Nature. 389(6654):990-4.
  2. Ishizaki T. et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. (2000) Mol Pharmacol 57, 976-983.
  3. Koyanagi et al. Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors. (2008) J. Neurosci Res 86: 270-280.
  4. Watanabe et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. (2007) Nat Biotech 25: 681-686.

Products are for research use only. Not for human use.


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