PD0325901, MEK Inhibitor


Catalog No. size PriceQuantity
M60018-2D 10 mM in DMSO (0.415 mL) $79
M60018-2S 2 mg solid $79
M60018-25S 25mg solid $350

Description

Product Information
Molecular Weight: 482.19
Formula: C16H14F3IN2O4
Purity: ≥98%
CAS#: 391210-10-9
Solubility: DMSO up to 100 mM
Chemical Name: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2[(2-fluoro-4-iodophenyl)amino]-benzamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

PD0325901 is a highly potent and selective inhibitor of MEK with an IC50 of 0.33 nM. Its potency, selectivity, and solubility are all better than many other MEK inhibitors (e.g., CI-1040). It can potently inhibit the phosphorylation and activation of MAPK/ERK and tumor cell proliferation. In combination with CHIR99021, PD0325901 has been shown to promote mouse ES cell self-renewal and iPSC generation.

 


How to Use:

 

  • In vitro: PD0325901 was used at 0.01-0.5 µM in vitro and in cellular assays.
  • In vivo: PD0325901 was orally administrated to mice at 25 mg/kg once per day. 

 

 

Reference:

  1. Barrett SD, et al. The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. (2008) Bioorg. Med. Chem. Lett. 18: 6501-6504.
  2. Lin T, et al. A chemical platform for improved induction of human iPSCs. (2009) Nature Methods 6, 805-808.
  3. Henderson YC, et al. MEK inhibitor PD0325901 significantly reduces the growth of papillary thyroid carcinoma cells in vitro and in vivo. (2010) Mol Cancer Ther. 9(7):1968-76.

 


Products are for research use only. Not for human use.

Payment & Security

American Express Diners Club Discover JCB Mastercard PayPal Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed