PD0325901, MEK Inhibitor

Catalog No. size PriceQuantity
M60018-2D 10 mM in DMSO (0.415 mL) $79
M60018-2S 2 mg solid $79
M60018-25S 25mg solid $350


Product Information
Molecular Weight: 482.19
Formula: C16H14F3IN2O4
Purity: ≥98%
CAS#: 391210-10-9
Solubility: DMSO up to 100 mM
Chemical Name: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2[(2-fluoro-4-iodophenyl)amino]-benzamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.


Biological Activity:

PD0325901 is a highly potent and selective inhibitor of MEK with an IC50 of 0.33 nM. Its potency, selectivity, and solubility are all better than many other MEK inhibitors (e.g., CI-1040). It can potently inhibit the phosphorylation and activation of MAPK/ERK and tumor cell proliferation. In combination with CHIR99021, PD0325901 has been shown to promote mouse ES cell self-renewal and iPSC generation.


How to Use:


  • In vitro: PD0325901 was used at 0.01-0.5 µM in vitro and in cellular assays.
  • In vivo: PD0325901 was orally administrated to mice at 25 mg/kg once per day. 




  1. Barrett SD, et al. The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. (2008) Bioorg. Med. Chem. Lett. 18: 6501-6504.
  2. Lin T, et al. A chemical platform for improved induction of human iPSCs. (2009) Nature Methods 6, 805-808.
  3. Henderson YC, et al. MEK inhibitor PD0325901 significantly reduces the growth of papillary thyroid carcinoma cells in vitro and in vivo. (2010) Mol Cancer Ther. 9(7):1968-76.


Products are for research use only. Not for human use.

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