PD0325901 is a highly potent and selective inhibitor of MEK with an IC50 of 0.33 nM. Its potency, selectivity, and solubility are all better than many other MEK inhibitors (e.g., CI-1040). It can potently inhibit the phosphorylation and activation of MAPK/ERK and tumor cell proliferation. In combination with CHIR99021, PD0325901 has been shown to promote mouse ES cell self-renewal and iPSC generation.
CAS Number: 391210-10-9
Molecular Weight: 482.19
Chemical Name: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2[(2-fluoro-4-iodophenyl)amino]-benzamide
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 100 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
PD0325901 was used at 0.01-0.5 µM in vitro and in cellular assays.
PD0325901 was orally administrated to mice at 25 mg/kg once per day.
- Barrett SD, et al. The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. (2008) Bioorg. Med. Chem. Lett. 18: 6501-6504.
- Lin T, et al. A chemical platform for improved induction of human iPSCs. (2009) Nature Methods 6, 805-808.
- Henderson YC, et al. MEK inhibitor PD0325901 significantly reduces the growth of papillary thyroid carcinoma cells in vitro and in vivo. (2010) Mol Cancer Ther. 9(7):1968-76.
Products are for research use only. Not for human use.
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