P22077 --- USP7 inhibitor


Catalog No. size PriceQuantity
M60019-2D 10 mM in DMSO (0.635 mL) $99
M60019-2S 2 mg solid $99
M60019-10S 10 mg solid $391

Description

P22077 is a potent and selective USP7 inhibitor that was recently identified using an Ub-CHOP reporter assay. It was shown to have potent and selective inhibitory activity against USP7 and closely related USP47 at ~5 µM, but not other DUBs (at ~15-45 µM). USP7, also known as HAUSP, plays an important role in cancer progression as it affects the stability of p53. The inhibition of USP7 is predicted to destabilize HDM2 and stabilize p53, and USP7 exerts both p53-dependent and p53-independent effects on controlling cell proliferation and apoptosis.

Product information

CAS Number: 1247819-59-5

Molecular Weight: 315.32

Formula: C12H7F2NO3S2

Chemical Name: 1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone

Smiles: CC(=O)C1=CC(=C(SC2=CC=C(F)C=C2F)S1)[N+]([O-])=O

InChiKey: RMAMGGNACJHXHO-UHFFFAOYSA-N

InChi: InChI=1S/C12H7F2NO3S2/c1-6(16)11-5-9(15(17)18)12(20-11)19-10-3-2-7(13)4-8(10)14/h2-5H,1H3

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

P22077 was used at 25 µM in vitro and in cells.

References:

  1. Mikael Altun et al. Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes. (2011) Chemistry & Biology 18, 1401–1412.
  2. Nicholson B, et al. The multifaceted roles of USP7: new therapeutic opportunities. (2011) Cell Biochem Biophys. 60(1-2):61-8.

Products are for research use only. Not for human use.


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