Forskolin is a small molecule activator of adenylate cyclase (EC50~5-10 µM) in a rapid and reversible manner, to increase the intracellular levels of cAMP. Forskolin is used in many stem cell differentiation conditions, such as potentiating neuronal differentiation.
CAS Number: 66428-89-5
Molecular Weight: 410.50
Chemical Name: (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetat
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 100 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
Forskolin is used at 10-50 µM final concentration in cell cultures.
Forskolin lowered blood pressure in hypertensive rats by 10 mg/kg oral dosing once per day.
- Kenneth Seamon, et al. Forskolin: Unique diterpene activator of adenylate cyclase in membranes and in intact cells. (1981) PNAS Vol. 78, No. 6, pp. 3363-3367.
- Hedin L. et al. Forskolin effects on the cAMP system and steroidogenesis in the immature rat ovary. (1983) Mol Cell Endocrinol 33: 69-80.
- Kilmer SL, et al. Forskolin activation of adenylate cyclase in vivo stimulates nerve regeneration. (1984) Nature. 307(5950):455-7.
- Son H. et al. Pairing of forskolin and KCl increases differentiation of immortalized hippocampal neurons in a CREB Serine 133 phosphorylation-dependent and extracellular-regulated protein kinase-independent manner. (2001) Neurosci Lett 308: 37-40.
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