Description
PS48 is a novel PDK1 (phosphoinositide-dependent protein kinase 1) activator (Kd = 10.3 μM), which binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 has been used to enhance iPSC reprogramming from human epidermal keratinocytes and endothelial cells.
Product information
CAS Number: 1180676-32-7
Molecular Weight: 286.75
Formula: C17H15ClO2
Synonym:
PS-48
Chemical Name: 5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid
Smiles: OC(=O)C=C(CCC1C=CC(Cl)=CC=1)C1C=CC=CC=1
InChiKey: LLJYFDRQFPQGNY-QINSGFPZSA-N
InChi: InChI=1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12-
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 100 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
In Vitro:
PS48 was used at 5 µM concentration in cell culture.
References:
- Hindie V, et al. Structure and allosteric effects of low-molecular- weight activators on the protein kinase PDK1. (2009) Nature Chem Biol. 5: 758-764.
- Stroba A, et al. 3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds. (2009) J Med Chem. 52(15):4683-93.
- Zhu S, et al. Reprogramming of Human Primary Somatic Cells by Oct4 and Chemical Compounds. (2010) Cell Stem Cell. 7 (6)651-655.
Products are for research use only. Not for human use.
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