Pyrintegrin---Cell Survival Enhancer


Catalog No. size PriceQuantity
M60028-2D 10 mM in DMSO (0.443 mL) $109
M60028-2S 2 mg solid $109
M60028-10S 10mg solid $436

Description

Product Information
Molecular Weight: 451.54
Formula: C23H25N5O3S
Purity: ≥98%
CAS#: 1228445-38-2
Solubility: DMSO up to 100 mM
Chemical Name: N-(cyclopropylmethyl)-4-((4-(6-hydroxy-3,4-dihydroquinolin-1(2H)-yl)pyrimidin-2-yl)amino)benzenesulfonamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

Pyrintegrin is a cell-permeable small molecule that promotes human embryonic stem cell (hESC) survival by > 30-fold. Pyrintegrin can enhance cell-ECM adhesion-mediated integrin signaling. It can also stabilize the cell surface protein E-cadherin after cell dissociation.

 


How to Use:

 

  • In vitro: Pyrintegrin was used at 3-5 µM concentration in cell culture.
  • In vivo: n/a

 

 


Reference:

  1. Xu Y, et al. Revealing a core signaling regulatory mechanism for pleuripotent stem cell survival and self-renewal by small molecules. (2010) PNAS 107(18): 8129-8134.

 

     

 

 

 

Products are for research use only. Not for human use.

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