Pyrintegrin---Cell Survival Enhancer


Catalog No. size PriceQuantity
M60028-2D 10 mM in DMSO (0.443 mL) $109
M60028-2S 2 mg solid $109
M60028-10S 10mg solid $436

Description

Pyrintegrin is a cell-permeable small molecule that promotes human embryonic stem cell (hESC) survival by > 30-fold. Pyrintegrin can enhance cell-ECM adhesion-mediated integrin signaling. It can also stabilize the cell surface protein E-cadherin after cell dissociation.

Product information

CAS Number: 1228445-38-2

Molecular Weight: 451.54

Formula: C23H25N5O3S

Chemical Name: N-(cyclopropylmethyl)-4-((4-(6-hydroxy-3,4-dihydroquinolin-1(2H)-yl)pyrimidin-2-yl)amino)benzenesulfonamide

Smiles: OC1=CC2CCCN(C=2C=C1)C1=CC=NC(NC2C=CC(=CC=2)S(=O)(=O)NCC2CC2)=N1

InChiKey: QRJTZIJWDLJKQO-UHFFFAOYSA-N

InChi: InChI=1S/C23H25N5O3S/c29-19-7-10-21-17(14-19)2-1-13-28(21)22-11-12-24-23(27-22)26-18-5-8-20(9-6-18)32(30,31)25-15-16-3-4-16/h5-12,14,16,25,29H,1-4,13,15H2,(H,24,26,27)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Pyrintegrin was used at 3-5 µM concentration in cell culture.

References:

  1. Xu Y, et al. Revealing a core signaling regulatory mechanism for pleuripotent stem cell survival and self-renewal by small molecules. (2010) PNAS 107(18): 8129-8134.

Products are for research use only. Not for human use.


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