Description
Pyrintegrin is a cell-permeable small molecule that promotes human embryonic stem cell (hESC) survival by > 30-fold. Pyrintegrin can enhance cell-ECM adhesion-mediated integrin signaling. It can also stabilize the cell surface protein E-cadherin after cell dissociation.
Product information
CAS Number: 1228445-38-2
Molecular Weight: 451.54
Formula: C23H25N5O3S
Chemical Name: N-(cyclopropylmethyl)-4-((4-(6-hydroxy-3,4-dihydroquinolin-1(2H)-yl)pyrimidin-2-yl)amino)benzenesulfonamide
Smiles: OC1=CC2CCCN(C=2C=C1)C1=CC=NC(NC2C=CC(=CC=2)S(=O)(=O)NCC2CC2)=N1
InChiKey: QRJTZIJWDLJKQO-UHFFFAOYSA-N
InChi: InChI=1S/C23H25N5O3S/c29-19-7-10-21-17(14-19)2-1-13-28(21)22-11-12-24-23(27-22)26-18-5-8-20(9-6-18)32(30,31)25-15-16-3-4-16/h5-12,14,16,25,29H,1-4,13,15H2,(H,24,26,27)
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 100 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
In Vitro:
Pyrintegrin was used at 3-5 µM concentration in cell culture.
References:
- Xu Y, et al. Revealing a core signaling regulatory mechanism for pleuripotent stem cell survival and self-renewal by small molecules. (2010) PNAS 107(18): 8129-8134.
Products are for research use only. Not for human use.
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