Rapamycin is a potent and selective mTOR inhibitor. Rapamycin, in complex with the cytosolic protein FK-binding protein 12 (FKBP12), inhibits mTOR Complex 1 (mTORC1) by binding to the FRB domain of mTor. Given the central roles mTor plays, Rapamycin showed diverse activities, including anti-proliferative effects in cancer cells, immunosuppressive effect, lifespan extension in mice, improved cognition in the mouse model of autism and Alzheimer, and inducing autophagy.
CAS Number: 53123-88-9
Molecular Weight: 914.17
Chemical Name: (3S, 6R, 7E, 9R, 10R, 12R, 14S, 15E, 17E, 19E, 21S, 23S, 26R, 27R, 34aS)- 9, 10, 12, 13, 14, 21, 22, 23, 24, 25, 26, 27, 32, 33, 34, 34a-hexadecahydro-9, 27-dihydroxy-3- [(1R)-2-[(1S, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10, 21-dimethoxy-6, 8, 12, 14, 20, 26- hexamethyl-23, 27-epoxy-3H-pyrido[2, 1-c][1, 4]-oxaazacyclohentriacontine-1, 5, 11, 28, 29 (4H, 6H, 31H)- pentone
Smiles: CC1=C[C@@H](C)C(=O)C[C@H](OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@H](C[C@H](OC)C(C)=CC=CC=C[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@@H]1O)CC[C@H]2C)[C@H](C)C[C@H]1C[C@@H](OC)[C@H](O)CC1 |c:1,t:32,34,36|
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 50 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
Rapamycin is usually used at 1 µM final concentration in vitro and in cellular assays.
Rapamycin could be orally administrated to mice at 5-20 mg/kg once per day.
- Vézina C, et al. Rapamycin (AY-22,989), a new antifungal antibiotic. (1975) J. Antibiot. 28 (10): 721.
- Heitman J, et al. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. (1991) Science. 253: 905-909.
- Price DJ, et al. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. (1992) Science. 257: 973-977.
- Wells AD, et al. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. (1999) Nat. Med.5:1303-1307.
Products are for research use only. Not for human use.
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