Rapamycin, mTOR inhibitor


Catalog No. size PriceQuantity
M60029-5D 10 mM in DMSO (0.547 mL) $89
M60029-5S 5mg solid $89
M60029-10S 10mg solid $360

Description

Product Information
Molecular Weight: 914.17
Formula: C51H79NO13
Purity: ≥98%
CAS#: 53123-88-9
Solubility: DMSO up to 50 mM
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

Rapamycin is a potent and selective mTOR inhibitor. Rapamycin, in complex with the cytosolic protein FK-binding protein 12 (FKBP12), inhibits mTOR Complex 1 (mTORC1) by binding to the FRB domain of mTor. Given the central roles mTor plays, Rapamycin showed diverse activities, including anti-proliferative effects in cancer cells, immunosuppressive effect, lifespan extension in mice, improved cognition in the mouse model of autism and Alzheimer, and inducing autophagy.

 


How to Use:

 

  • In vitro: Rapamycin is usually used at 1 µM final concentration in vitro and in cellular assays.
  • In vivo: Rapamycin could be orally administrated to mice at 5-20 mg/kg once per day.

 

 


Reference:

  1. Vézina C, et al. Rapamycin (AY-22,989), a new antifungal antibiotic. (1975) J. Antibiot. 28 (10): 721.
  2. Heitman J, et al. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. (1991) Science. 253: 905-909.
  3. Price DJ, et al. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. (1992) Science. 257: 973-977.
  4. Wells AD, et al. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. (1999) Nat. Med.5:1303-1307.
  5. Wendel HG, et al. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. (2004) Nature 428 (6980): 332–7.
  6. Ehninger D, et al. Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis. (2008) Nat. Med. 14 (8): 843–8
  7. Harrison DE, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. (2009) Nature 460 (7253): 392–5.



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