CASIN --- Cdc42 Inhibitor


Catalog No. size PriceQuantity
M60040-2D 10 mM in DMSO (0.654 mL) $139
M60040-2S 2 mg solid $139
M60040-10S 10 mg solid $350
M60040-100S 100 mg solid $850

Description

CASIN is a novel and potent Cdc42 inhibitor with an IC50 ~2 µM. In a recent publication in Cell Stem Cell, the elevated activity of the small RhoGTPase Cdc42 in aged HSCs was shown to be causally linked to HSC aging and correlate with a loss of polarity in aged HSCs. CASIN as a specific inhibitor of Cdc42 was shown to functionally rejuvenate aged HSCs, increase the percentage of polarized cells in an aged HSC population, and restore the level and spatial distribution of histone H4 lysine 16 acetylation to a status similar to that seen in young HSCs. CASIN-treated HSCs were further shown to engraft long term in vivo with enhanced repopulation ability.

Product information

CAS Number: 425399-05-9

Molecular Weight: 306.40

Formula: C20H22N2O

Chemical Name: 2-((6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino)ethanol

Smiles: OCCNC1CCCC2=C1NC1=CC=C(C=C21)C1C=CC=CC=1

InChiKey: RXIUMAOXORBRCY-UHFFFAOYSA-N

InChi: InChI=1S/C20H22N2O/c23-12-11-21-19-8-4-7-16-17-13-15(14-5-2-1-3-6-14)9-10-18(17)22-20(16)19/h1-3,5-6,9-10,13,19,21-23H,4,7-8,11-12H2

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

CASIN was used at 5 µM final concentration in the in vitro assays and ex vivo treatment of HSCs.

In Vivo:

not reported yet.

References:

  1. Florian MC, et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. (2012) Cell Stem Cell. 10(5):520-30.
  2. Carrillo-García C, et al. Restoring cell polarity: an HSC fountain of youth. (2012) Cell Stem Cell. 10(5):481-2

Products are for research use only. Not for human use.


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