JK184 --- Hedgehog Antagonist

Catalog No. size PriceQuantity
M60087-5S 5mg solid $79
M60087-10S 10mg solid $328


JK184 is a potent and cell-permeable inhibitor of hedgehog (Hh) signaling downstream of Smo, identified by a cell-based Hh pathway reporter screening. JK184 was found to inhibit Adh7 (IC50 ~210 nM), the class IV alcohol dehydrogenase as well as act as a microtubule depolymerizing agent in vitro. JK184 inhibits Hh agonit-induced Gli transcriptional activity (IC50 ~30 nM) as well as Gli1 and Ptc1 mRNA expression in a dose-dependent manner in 10T1/2 cells. It shows antiproliferative activity in a range of cancer cell lines (IC50 ~ 3 - 21 nM), and inhibits the growth of two xenografted tumors in mice in vivo.

Product information

CAS Number: 315703-52-7

Molecular Weight: 350.44

Formula: C19H18N4OS

Chemical Name: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine

Smiles: CC1N=C2C=CC=CN2C=1C1=CSC(NC2=CC=C(C=C2)OCC)=N1


InChi: InChI=1S/C19H18N4OS/c1-3-24-15-9-7-14(8-10-15)21-19-22-16(12-25-19)18-13(2)20-17-6-4-5-11-23(17)18/h4-12H,3H2,1-2H3,(H,21,22)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

JK184 was suggested to use at 1-5 µM concentration in vitro and in the cellular assays.

In Vivo:

JK184 was dosed orally 0.2 mg/mouse once per day.


  1. Lee J, et al. A small-molecule antagonist of the hedgehog signaling pathway. (2007) Chembiochem 8(16):1916-9.
  2. Cupido T, et al. The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling. (2009)Angew Chem Int Ed Engl. 48(13):2321-4.

Products are for research use only. Not for human use.


Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed