Optovin --- TRPA1 Activator


Catalog No. size PriceQuantity
M60103-2S 2 mg solid $129
M60103-10S 10mg solid $510

Description

Optovin is a potent and selective small molecule activator of human TRPA1, identified through a high throughput zebrafish behavior screening. It activates human TRPA1 via photochemical reactions with redox-sensitive cysteine residues (EC50 ~2 µM), and enables repeated photoactivation of motor behaviors in wild-type zebrafish and mice. Optovin’s behavioral effects are not visually mediated. Rather, photodetection is performed by sensory neurons expressing the cation channel TRPA1. In animals with severed spinal cords, optovin treatment enables control of motor activity in the paralyzed extremities by localized illumination. These studies identify a light-based strategy for controlling endogenous TRPA1 receptors in vivo, with potential clinical and research applications in nontransgenic animals, including humans.

Product information

CAS Number: 348575-88-2

Molecular Weight: 315.41

Formula: C15H13N3OS2

Chemical Name: (E)-5-((2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl)methylene)-2-thioxothiazolidin-4-one

Smiles: CC1=C(/C=C2/SC(=S)NC/2=O)C=C(C)N1C1=CN=CC=C1

InChiKey: YISGMOZSGOGYOU-NTUHNPAUSA-N

InChi: InChI=1S/C15H13N3OS2/c1-9-6-11(7-13-14(19)17-15(20)21-13)10(2)18(9)12-4-3-5-16-8-12/h3-8H,1-2H3,(H,17,19,20)/b13-7+

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 50 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Optovin was used at 10 µM final concentration in vitro and in cellular assays.

In Vivo:

Optovin was suggested to be delivered on the ear for 20 μL of optovin solution (15 mM in DMSO).

References:

  1. Kokel D, et al. Photochemical activation of TRPA1 channels in neurons and animals. (2013) Nat Chem Biol. 9(4):257-63.

Products are for research use only. Not for human use.


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