HIF-C2, HIF-2 Inhibitor

Catalog No. size PriceQuantity
M60121-2D 10 mM in DMSO (0.648 mL) $139
M60121-2S 2mg solid $139
M60121-10S 10 mg solid $556


Product Information
Molecular Weight: 308.65
Formula: C12H6ClFN4O3
Purity: ≥98%
CAS#: 1422955-31-4
Solubility: DMSO up to 50 mM
Chemical Name: N-(3-chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.


Biological Activity:

HIF-C2 is a potent and selective allosteric inhibitor of hypoxia inducible factor-2 (HIF-2). It binds within the internal cavity of HIF-2α PAS-B (Kd of 81 nM) and disrupts heterodimerization of the full-length HIF-2 transcription factor. HIF-C2 functions effectively as a HIF-2 inhibitor in living cells, disrupting HIF-2 DNA binding and inhibiting the transcription of its target genes. Moreover, HIF-C2 is selective for the HIF-2 isoform and has no activity to antagonize HIF-1. HIF-C2 provides an opportunity to delineate differences in HIF-1 and HIF-2 biology and serves as an entry point for development of HIF-2 inhibitor drugs for treating diseases, including renal cell carcinomas.




How to Use: 


  • In vitro:  HIF-C2 was used at 10 µM final concentration in vitro and in cellular assays.
  • In vivo:  n/a




  • 1. Scheuermann TH, et al. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. (2013) Nat Chem Biol 9(4):271-6.
  • 2. Rogers JL, et al. Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor. (2013) J Med Chem. 56(4):1739-47.



Products are for research use only. Not for human use.

Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed