CAS Number: 1597403-47-8
Molecular Weight: 451.34
Chemical Name: N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide)
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 100 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
Trans-ISRIB was used at 0.2 µM final concentration in various in vitro assays.
Trans-ISRIB could be dosed to the mice by intraperitoneal injection at 2.5-5 mg/kg administration single dose. Trans-ISRIB displayed a half-life in plasma of 8 hr and readily crossed the blood-brain barrier, quickly equilibrating with the central nervous system.
- Sidrauski C, et al. Pharmacological brake-release of mRNA translation enhances cognitive memory. (2013) Elife. 2:e00498.
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