FPH1, Hepatocytes Functional Proliferation Inducer

Catalog No. size PriceQuantity
M60126-2S 2mg solid $139
M60126-10S 10 mg solid $563


Product Information
Molecular Weight: 388.82
Formula: C16H15ClF2N2O3S
Purity: ≥98%
CAS#: 708219-39-0
Solubility: DMSO up to 100 mM
Chemical Name: 2-(N-(5-chloro-2-methylphenyl)methylsulfonamido)-N-(2,6-difluorophenyl)acetamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.


Biological Activity:

FPH1 is a potent and selective small molecule that induced Functional Proliferation of primary human Hepatocytes in vitro, identified by a high-throughput, cell-based screening using primary human hepatocytes. It induced a significant increase in hepatocyte number and elevated the number of hepatocytes undergoing mitosis in a dose-dependent manner. Cells treated with FPH1 also maintained their liver-specific functions. Immunofluorescence staining for Ki67 and albumin, along with FACS-based cell counting, revealed that hepatocytes from a wide range of genetically diverse individuals could be expanded and normal hepatocytes functions could be maintained after expansion. FPH1 can also promote the differentiation of iPS cells toward a hepatic lineage and promote the maturation of induced hepatic cells toward a more adult-like liver phenotype.

How to Use: 

  • In vitro: FPH1 was suggested to be supplemented into the culture medium on day 1 and 5 at a concentration of 15-20 μM to  induce functional proliferation of primary human hepatocytes in vitro.
  • In vivo: n/a


  • 1. Shan J, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. (2013) Nat Chem Biol. 9(8):514-20. 


Products are for research use only. Not for human use.


Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed