FPH1, Hepatocytes Functional Proliferation Inducer


Catalog No. size PriceQuantity
M60126-2S 2mg solid $139
M60126-10S 10 mg solid $563

Description

Product Information
Molecular Weight: 388.82
Formula: C16H15ClF2N2O3S
Purity: ≥98%
CAS#: 708219-39-0
Solubility: DMSO up to 100 mM
Chemical Name: 2-(N-(5-chloro-2-methylphenyl)methylsulfonamido)-N-(2,6-difluorophenyl)acetamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

FPH1 is a potent and selective small molecule that induced Functional Proliferation of primary human Hepatocytes in vitro, identified by a high-throughput, cell-based screening using primary human hepatocytes. It induced a significant increase in hepatocyte number and elevated the number of hepatocytes undergoing mitosis in a dose-dependent manner. Cells treated with FPH1 also maintained their liver-specific functions. Immunofluorescence staining for Ki67 and albumin, along with FACS-based cell counting, revealed that hepatocytes from a wide range of genetically diverse individuals could be expanded and normal hepatocytes functions could be maintained after expansion. FPH1 can also promote the differentiation of iPS cells toward a hepatic lineage and promote the maturation of induced hepatic cells toward a more adult-like liver phenotype.

How to Use: 

  • In vitro: FPH1 was suggested to be supplemented into the culture medium on day 1 and 5 at a concentration of 15-20 μM to  induce functional proliferation of primary human hepatocytes in vitro.
  • In vivo: n/a

Reference:

  • 1. Shan J, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. (2013) Nat Chem Biol. 9(8):514-20. 

 


Products are for research use only. Not for human use.

 

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