FH1 is a potent and selective small molecule that enhances hepatocyte functions and promotes the differentiation and maturation of iPSC-derived hepatocytes toward a more mature phenotype in vitro. FH1 was identified by a high-throughput, cell-based screening using primary human hepatocytes. It was added to the basal medium with or without OSM on day 21 after the initiation of differentiation of iPSCs and acted over a period of 9 day to promote more pronounced hepatocyte morphologies, including polygonal cell shapes, visible nuclei and more noticeable bile canaliculi between hepatocytes.
CAS Number: 2719-05-3
Molecular Weight: 282.34
functional hits 1
Chemical Name: N,N'-(methylenebis(4,1-phenylene))diacetamide
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 100 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
FH1 was suggested to be supplemented into the culture medium on day 21 at a concentration of 15-20 μM to enhance hepatocyte functions in vitro over period of 9 days.
- Shan J, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. (2013) Nat Chem Biol. 9(8):514-20.
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