FH1, Hepatocytes Functional Enhancer


Catalog No. size PriceQuantity
M60127-2S 2 mg solid $139
M60127-10S 10mg solid $549

Description

FH1 is a potent and selective small molecule that enhances hepatocyte functions and promotes the differentiation and maturation of iPSC-derived hepatocytes toward a more mature phenotype in vitro. FH1 was identified by a high-throughput, cell-based screening using primary human hepatocytes. It was added to the basal medium with or without OSM on day 21 after the initiation of differentiation of iPSCs and acted over a period of 9 day to promote more pronounced hepatocyte morphologies, including polygonal cell shapes, visible nuclei and more noticeable bile canaliculi between hepatocytes.

Product information

CAS Number: 2719-05-3

Molecular Weight: 282.34

Formula: C17H18N2O2

Synonym:

BRD-K4477

functional hits 1

Chemical Name: N,N'-(methylenebis(4,1-phenylene))diacetamide

Smiles: CC(=O)NC1C=CC(CC2C=CC(=CC=2)NC(C)=O)=CC=1

InChiKey: OEXMNSOPAKOPEF-UHFFFAOYSA-N

InChi: InChI=1S/C17H18N2O2/c1-12(20)18-16-7-3-14(4-8-16)11-15-5-9-17(10-6-15)19-13(2)21/h3-10H,11H2,1-2H3,(H,18,20)(H,19,21)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

FH1 was suggested to be supplemented into the culture medium on day 21 at a concentration of 15-20 μM to enhance hepatocyte functions in vitro over period of 9 days.

References:

  1. Shan J, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. (2013) Nat Chem Biol. 9(8):514-20.

Products are for research use only. Not for human use.

Payment & Security

American Express Diners Club Discover JCB Mastercard PayPal Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed