FH1, Hepatocytes Functional Enhancer


Catalog No. size PriceQuantity
M60127-2S 2 mg solid $139
M60127-10S 10mg solid $549

Description

Product Information
Molecular Weight: 282.34
Formula: C17H18N2O2
Purity: ≥98%
CAS#: 2719-05-3
Solubility: DMSO up to 100 mM
Chemical Name: N,N'-(methylenebis(4,1-phenylene))diacetamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

FH1 is a potent and selective small molecule that enhances hepatocyte functions and promotes the differentiation and maturation of iPSC-derived hepatocytes toward a more mature phenotype in vitro. FH1 was identified by a high-throughput, cell-based screening using primary human hepatocytes. It was added to the basal medium  with or without OSM on day 21 after the initiation of differentiation of iPSCs and acted over a period of 9 day to promote more pronounced hepatocyte morphologies, including polygonal cell shapes, visible nuclei and more noticeable bile canaliculi between hepatocytes.

How to Use:

  • In vitro:  FH1 was suggested to be supplemented into the culture medium on day 21 at a concentration of 15-20 μM to enhance hepatocyte functions in vitro over period of 9 days.
  • In vivo: n/a

Reference:

  • 1. Shan J, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. (2013) Nat Chem Biol. 9(8):514-20. 
 

Products are for research use only. Not for human use.

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