SKPin C1 --- Skp2 Inhibitor

Catalog No. size PriceQuantity
M60137-2S 2 mg solid $109
M60137-10S 10mg solid $436


SKPin C1 is a potent and selective inhibitor of Skp2-mediated p27 degradation. It selectively inhibited Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts. In cancer cells, the compounds induced p27 accumulation in a Skp2-dependent manner and promoted cell-type-specific blocks in the G1 or G2/M phases. SKPin C1 is a useful chemical probe selectively targeting SCF-Skp2 protein-protein interface, may provide a new avenue of cancer treatment with enhanced specificity over Bortezomib.

Product information

CAS Number: 432001-69-9

Molecular Weight: 465.34

Formula: C18H13BrN2O4S2

Chemical Name: (Z)-2-(4-bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid

Smiles: OC(=O)COC1=CC=C(Br)C=C1/C=C1\SC(=S)N(CC2C=CC=NC=2)C\1=O


InChi: InChI=1S/C18H13BrN2O4S2/c19-13-3-4-14(25-10-16(22)23)12(6-13)7-15-17(24)21(18(26)27-15)9-11-2-1-5-20-8-11/h1-8H,9-10H2,(H,22,23)/b15-7-

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 10 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

SKPin C1 was used at 10 µM final concentration in various in vitro assays.


  1. Wu L, et al. Specific small molecule inhibitors of Skp2-mediated p27 degradation. (2012) Chem Biol. 19(12):1515-24.

Products are for research use only. Not for human use.


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