ZLN005---PGC-1α Transcriptional Activator


Catalog No. size PriceQuantity
M60142-5S 5mg solid $69
M60142-10S 10mg solid $328

Description


Product Information
Molecular Weight: 250.34
Formula: C17H18N2
Purity: ≥98%
CAS#: 49671-76-3
Solubility: DMSO up to 100 mM
Chemical Name: 2-(4-(tert-butyl)phenyl)-1H-benzo[d]imidazole
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

ZLN005 is a potent and selective small molecule PGC-1α transcriptional activator. It stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation. Chronic oral administration of ZLN005 at 15 mg/kg per day to diabetic db/db mice increased PGC-1α and downstream gene transcription in skeletal muscle, increasing fat oxidation and improving glucose tolerance, pyruvate tolerance, and insulin sensitivity. PGC-1α is a tissue-specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis. ZLN005 is a useful chemical probe to study this target.

 


How to Use:

 

  • In vitro:  ZLN005 was used at 10-20 µM final concentration in various in vitro assays.
  • In vivo: ZLN005 was orally administrated in db/db mice at 15 mg/kg once per day for 6 weeks.

 

 

Reference: 

  1. Zhang LN, et al. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. (2013) Diabetes. 62(4):1297-307.

 


 

Products are for research use only. Not for human use.


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