Bromosporine, Pan-bromodomain Inhibitor


Catalog No. size PriceQuantity
M60144-2D 10 mM in DMSO (0.494 mL) $129
M60144-2S 2 mg in solid $129
M60144-10S 10mg solid $529

Description

Product Information
Molecular Weight: 404.44
Formula: C17H20N6O4S
Purity: ≥98%
CAS#: n/a
Solubility: DMSO up to 100 mM
Chemical Name: ethyl (3-methyl-6-(4-methyl-3-(methylsulfonamido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

Bromosporine is a broad spectrum inhibitor for bromodomains with IC50 of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM for BRD2, BRD4, BRD9 and CECR2, respectively. In cell-based assays, Bromosporine (1 µM) accelerates FRAP recovery of BRD4 and CREBBP, while shows no activities against TIF1α, BAZ2A, and SMARCA2 (at 10 µM). Bromosporine shows moderate cytotoxicity in HeLa cells at 18 µM. It is a very useful chemical probe for bromodomain functional assays. 

 

How to Use:

In vitro:  Bromosporine was used at 1 µM final concentration in vitro and in cellular assays.

In vivo: n/a

 

Reference:

  1. http://www.thesgc.org/ 

Products are for research use only. Not for human use.

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