LMK235, HDAC4 and HDAC5 Inhibitor

Catalog No. size PriceQuantity
M60145-2D 10 mM in DMSO (0.679 mL) $89
M60145-2S 2mg solid $89
M60145-10S 10mg solid $365


Product Information
Molecular Weight: 294.35
Formula: C15H22N2O4
Purity: ≥98%
CAS#: 1418033-25-6
Solubility: DMSO up to 100 mM
Chemical Name: N-((6-(hydroxyamino)-6-oxohexyl)oxy)-3,5-dimethylbenzamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.


Biological Activity:

LMK235 is a potent and selective histone deacetylase HDAC4 and HDAC5 inhibitor  (IC50 ~11.9 nM and 4.22 nM respectively).  It also has inhibitory activities against HDAC 6, 1, 11, 2, and 8 with IC50 for 55.7, 320, 852, 881, and 1278 nM, respectively. LMK235 exhibits cytotoxity against chemo-resistant cancer cell lines in human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC50 ~0.49 and 0.32 μM respectively). 


How to Use: 


  • In vitro:  LMK235 was used at 1 µM final concentration in vitro and in cellular assays.
  • In vivo: n/a




  • 1. Marek L, et al. Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. (2013) J Med Chem. 56(2):427-36. 


Products are for research use only. Not for human use.

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