NU9056 is a selective KAT5 (Tip60) histone acetyltransferase inhibitor that inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. NU9056 also decreases proliferation of LNCaP cells and induces apoptosis via caspase activation.
CAS Number: 1450644-28-6
Molecular Weight: 232.37
Chemical Name: 1,2-di(isothiazol-5-yl)disulfane
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 100 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
NU9056 was used at 24 µM final concentration in vitro and in cellular assays.
- Coffey K, et al. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. (2012) PLoS One. 7(10):e45539.
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