AdipoRon, Adiponectin Receptor/AdipoR agonist


Catalog No. size PriceQuantity
M60152-2D 10 mM in DMSO (0.467 mL) $129
M60152-2S 2 mg solid $129
M60152-10S 10 mg solid $522

Description

Product Information
Molecular Weight: 428.52
Formula: C27H28N2O3
Purity: ≥98%
CAS#: 924416-43-3
Solubility: DMSO up to 50 mM
Chemical Name: 2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

AdipoRon is a novel, highly potent, selective and orally active small molecule agonist of adiponectin receptor (AdipoR). AdipoRon binds to both AdipoR1 and AdipoR2 (EC50 for AdipoR1 ~1.8 µM and AdipoR2 ~3.1 µM). AdipoRon showed very similar effects to adiponectin in muscle and liver, such as activation of AMPK and PPAR-α pathways, and ameliorated insulin resistance and glucose intolerance in mice fed with a high-fat diet, which was completely obliterated in AdipoR1 and AdipoR2 double-knockout mice. Moreover, AdipoRon ameliorated diabetes of genetically obese rodent model db/db mice, and prolonged the shortened lifespan of db/db mice on a high-fat diet. AdipoRon could serve as a very useful chemical probe for studies of obesity-related diseases such as type 2 diabetes by activating AdipoR1 and AdipoR2. 

 

How to Use:

In vitro:  AdipoRon was used at 10-25 µM final concentration in vitro and in cellular assays.

In vivo:  AdipoRon was administered orally to mice at 50 mg/kg once per day. 

 

Reference:

  • 1. Okada-Iwabu, et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. (2013) Nature. 503(7477):493-9. 

Products are for research use only. Not for human use.

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