OG-L002 --- LSD1 Inhibitor

Catalog No. size PriceQuantity
M60161-2S 2 mg solid $129
M60161-10S 10mg solid $529


OG-L002 is a highly potent and specific inhibitor of Lysine Specific Demethylase-1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50 ~20 nM, and has moderate inhibitory activity against monoamine oxidases MAO-A and MAO-B with IC50 ~1.38 µM and 0.72µM respectively. It potently repressed herpes simplex virus (HSV) IE gene expression, genome replication, and reactivation from latency. OG-L002 suppressed primary lytic infection of HSV in vivo in a mouse model.

Product information

CAS Number: 1357302-64-7

Molecular Weight: 225.29

Formula: C15H15NO

Chemical Name: 4'-((1S,2R)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol

Smiles: N[C@@H]1C[C@H]1C1C=CC(=CC=1)C1=CC(O)=CC=C1


InChi: InChI=1S/C15H15NO/c16-15-9-14(15)11-6-4-10(5-7-11)12-2-1-3-13(17)8-12/h1-8,14-15,17H,9,16H2/t14-,15+/m0/s1

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

OG-L002 was used at 1 µM in vitro.

In Vivo:

OG-L002 was administered by intraperitoneal injection once a day at a dose of 20-40 mg/kg to the primary infection mouse model.


  1. Liang Y, et al. A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. (2013) MBio. 4(1):e00558-12.

Products are for research use only. Not for human use.


Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed