WWL113 --- Ces3 and Ces1f Inhibitor


Catalog No. size PriceQuantity
M60162-2D 10 mM in DMSO (0.429 mL) $139
M60162-2S 2mg solid $139
M60162-10S 10mg solid $570

Description

WWL113 is a novel potent and selective inhibitor of Ces3 and Ces1f with IC50 ~0.1 µM in cellular assays. WWL113 was discovered by a high throughput screen. Carboxylesterase 3 (Ces3, also known as Ces1d) plays a key role in lipid metabolism (e.g., hydrolyzing long-chain fatty acid esters and thioesters) and promotes lipid storage in adipocytes. Ces3 activity is markedly elevated during adipocyte differentiation. Treatment of two mouse models of obesity/diabetes with WWL113 ameliorates multiple features of metabolic syndrome, including enhancing insulin sensitivity and glucose tolerance and reducing hepatic diacylglycerol species. WWL113 serves as a very useful chemical tool to pharmacologically validate Ces3 as a new therapeutic target.

Product information

CAS Number: 947669-86-5

Molecular Weight: 466.53

Formula: C29H26N2O4

Chemical Name: ethyl 4'-((methyl(3-(pyridin-4-yl)benzyl)carbamoyl)oxy)-[1,1'-biphenyl]-4-carboxylate

Smiles: CCOC(=O)C1=CC=C(C=C1)C1C=CC(=CC=1)OC(=O)N(C)CC1=CC=CC(=C1)C1=CC=NC=C1

InChiKey: AKIIPHDGVCFVCC-UHFFFAOYSA-N

InChi: InChI=1S/C29H26N2O4/c1-3-34-28(32)25-9-7-22(8-10-25)23-11-13-27(14-12-23)35-29(33)31(2)20-21-5-4-6-26(19-21)24-15-17-30-18-16-24/h4-19H,3,20H2,1-2H3

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 50 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

WWL113 was used at 10 µM final concentration in various in vitro assays.

In Vivo:

WWL113 was administered by oral dosing once a day at a dose of 30-50 mg/kg in the model of diet-induced obesity ordb/db mice.

References:

  1. Dominguez E, et al. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. (2014) Nat Chem Biol. 10(2):113-21.

Products are for research use only. Not for human use.


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