PBIT --- JARID1 Histone Demethylases Inhibitor

Catalog No. size PriceQuantity
M60170-2S 2 mg solid $129
M60170-10S 10 mg solid $535


PBIT is a potent, specific, reversible and cell-permeable inhibitor of Jumonji AT-Rich Interactive Domain 1 (JARID1) histone demethylases. It inhibits JARID1B (also known as KDM5B or PLU1) with an IC₅₀ of ~3 μM in vitro. It also inhibits the activity of other related histone demethylases JARID1A, JARID1C, and JMJD2E with IC50 ~6, 4.9, and 28 µM respectively. PBIT does not affect the activity of unrelated UTX and JMJD3 H3K27me3 demethylases. HeLa cells overexpressing full length JARID1B showed a significant increase in H3K4Me3 level following PBIT treatment (~10 µM). It blocks the proliferation of UACC-812 tumor cells expressing higher levels of JARDID1B, but does not significantly affect MCF7 or MCF10A cells expressing lower levels of JARDID1B.

Product information

CAS Number: 2514-30-9

Molecular Weight: 241.31

Formula: C14H11NOS

Chemical Name: 2-4(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one

Smiles: CC1C=CC(=CC=1)C1=CC=CC2SNC(=O)C=21


InChi: InChI=1S/C14H11NOS/c1-9-5-7-10(8-6-9)11-3-2-4-12-13(11)14(16)15-17-12/h2-8H,1H3,(H,15,16)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 50 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

PBIT was used at 10-30 µM in vitro.


  1. Sayegh J, et al. Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. (2013) J Biol Chem. 288(13):9408-17.

Products are for research use only. Not for human use.


Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed