GSK-LSD1, LSD1 Inhibitor


Catalog No. size PriceQuantity
M60179-2S 2mg solid $139
M60179-10S 10mg solid $570

Description

GSK-LSD1 is a highly potent, specific and irreversible inhibitor of Lysine Specific Demethylase-1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50 ~16 nM, and is > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B). GSK-LSD1 induces gene expression changes in cancer cell lines (average EC50 < 5 nM) and inhibits cancer cell line growth (average EC50 < 5 nM).

Product information

CAS Number: 2102933-95-7

Molecular Weight: 289.24

Formula: C14H22Cl2N2

Chemical Name: N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine HCl salt

Smiles: Cl.Cl.C1[C@H]([C@@H]1NC1CCNCC1)C1C=CC=CC=1

InChiKey: PJFZOGMSPBHPNS-WICJZZOFSA-N

InChi: InChI=1S/C14H20N2.2ClH/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12;;/h1-5,12-16H,6-10H2;2*1H/t13-,14+;;/m0../s1

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

GSK-LSD1 was used at 1 µM in vitro.

References:

  1. http://www.thesgc.org/chemical-probes/epigenetics

Products are for research use only. Not for human use.

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