GSK-LSD1, LSD1 Inhibitor


Catalog No. size PriceQuantity
M60179-2S 2mg solid $139
M60179-10S 10mg solid $570

Description

Product Information
Molecular Weight: 289.24
Formula: C14H22Cl2N2
Purity: ≥98%
CAS#:  2102933-95-7
Solubility: DMSO up to 100 mM
Chemical Name: N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine HCl salt
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

GSK-LSD1 is a highly potent, specific and irreversible inhibitor of Lysine Specific Demethylase-1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50 ~16 nM, and is > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B).  GSK-LSD1 induces gene expression changes in cancer cell lines (average EC50 < 5 nM) and inhibits cancer cell line growth (average EC50 < 5 nM). 

 

How to Use:

 

  • In vitro:  GSK-LSD1 was used at 1 µM in vitro.
  • In vivo:  n/a

 

 

Reference:

  • 1. http://www.thesgc.org/chemical-probes/epigenetics

Products are for research use only. Not for human use.

 

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