Fatostatin A is a highly potent, specific and cell permeable inhibitor of Sterol Regulatory Binding Proteins (SREBPs). It inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). It blocks adipogenesis by inhibiting the activation of SREBP-1 and SREBP-2. It exhibits anti-proliferative effects on DU 145 cells independently of IGF-1 signaling (IC50 ~0.1 μM). Fatostatin A can prevent increases in body weight, blood glucose and hepatic fat accumulation and reverses hyperglycemia in diabetic (ob/ob) mice, even under uncontrolled food intake. Fatostatin A may serve as a tool for gaining further insights into the regulation of SREBP.
CAS Number: 125256-00-0
Molecular Weight: 294.41
Related CAS Number:
Chemical Name: 2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 50 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
Fatostatin A was used at 10-20 µM in vitro.
Fatostatin A was delivered intraperitoneally at 30 mg/kg once daily for 28 days in ob/ob mice model.
- Choi Y, et al. Identification of bioactive molecules by adipogenesis profiling of organic compounds. (2003) J Biol Chem. 278(9):7320-4.
- Kamisuki S, et al. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. (2009) Chem Biol. 16(8):882-92.
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