Fatostatin A, Sterol Regulatory Binding Proteins (SREBPs) Inhibitor


Catalog No. size PriceQuantity
M60180-2S 2mg solid $79
M60180-10S 10 mg solid $320

Description

Product Information
Molecular Weight: 294.41
Formula: C18H18N2S
Purity: ≥98%
Relate CAS#: 298197-04-3(HBr)
CAS#: 125256-00-0
Solubility: DMSO up to 50 mM
Chemical Name: 2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

Fatostatin A is a highly potent, specific and cell permeable inhibitor of Sterol Regulatory Binding Proteins (SREBPs). It inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). It blocks adipogenesis by inhibiting the activation of SREBP-1 and SREBP-2. It exhibits anti-proliferative effects on DU 145 cells independently of IGF-1 signaling (IC50~0.1 μM). Fatostatin A can prevent increases in body weight, blood glucose and hepatic fat accumulation and reverses hyperglycemia in diabetic (ob/ob) mice, even under uncontrolled food intake. Fatostatin A may serve as a tool for gaining further insights into the regulation of SREBP. 

How to Use:

  • In vitro:  Fatostatin A was used at 10-20 µM in vitro.
  • In vivo:  Fatostatin A was delivered intraperitoneally at 30 mg/kg once daily for 28 days in ob/ob mice model.

Reference: 

  • 1. Choi Y, et al. Identification of bioactive molecules by adipogenesis profiling of organic compounds. (2003) J Biol Chem. 278(9):7320-4.
  • 2. Kamisuki S, et al. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. (2009) Chem Biol. 16(8):882-92. 

Products are for research use only. Not for human use.

Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed