PFI-2, SETD7 Histone Lysine Methyltransferase Inhibitor


Catalog No. size PriceQuantity
M60182-2S 2 mg solid $139
M60182-10S 10mg solid $563

Description

Product Information
Molecular Weight: 499.52
Formula: C23H25F4N3O3S
Purity: ≥98%
CAS#: 1627676-59-8
Solubility: DMSO up to 100 mM
Chemical Name: (R)-8-fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC50 ~2 nM. It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets. PFI-2 has been shown to bind to SETD7 by ITC (Kd=18nM), and biotinylated PFI-2 interacts with SETD7 in pull-down studies.

 


How to Use:

 

 

  • In vitro: PFI-2 was used at 1 µM in vitro.
  • In vivo: n/a

 

 


Reference:

 

  1. http://www.thesgc.org/chemical-probes/epigenetics

 


 

Products are for research use only. Not for human use.

Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed