PFI-2, SETD7 Histone Lysine Methyltransferase Inhibitor

Catalog No. size PriceQuantity
M60182-2S 2 mg solid $139
M60182-10S 10mg solid $563


Product Information
Molecular Weight: 499.52
Formula: C23H25F4N3O3S
Purity: ≥98%
CAS#: 1627676-59-8
Solubility: DMSO up to 100 mM
Chemical Name: (R)-8-fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.


Biological Activity:

PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC50 ~2 nM. It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets. PFI-2 has been shown to bind to SETD7 by ITC (Kd=18nM), and biotinylated PFI-2 interacts with SETD7 in pull-down studies.


How to Use:



  • In vitro: PFI-2 was used at 1 µM in vitro.
  • In vivo: n/a








Products are for research use only. Not for human use.

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