MHY1485, mTOR Activator


Catalog No. size PriceQuantity
M60189-5S 5 mg solid $79
M60189-10S 10mg solid $396

Description

Product Information
Molecular Weight: 387.39
Formula: C17H21N7O4
Purity: ≥98%
CAS#: 326914-06-1
Solubility: DMSO up to 10 mM
Chemical Name: 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

MHY1485 is a novel potent, selective and cell-permeable mTOR activator. It suppressed the basal autophagic flux, and this inhibitory effect was clearly confirmed in cells under starvation, a strong physiological inducer of autophagy. It can increase cellular mTOR Ser2448 and downstream substrate 4E-BP Thr37/46 phosphorylation level in rat liver Ac2F cells (1 to 2 µM for 1 h). It affects culture viability only at much higher concentrations (by 20% after 24 h 20 µM treatment). MHY1485 induced cellular LC3-II accumulation in Ac2F is reported to be a result of autophagy inhibition due to reduced fusion between autophagosomes and lysosomes. MHY1485 serves as a novel inhibitor of autophagy with an mTOR activating effect.

 

How to Use:

 

  • In vitro: MHY1485 was used at 1-5 µM in vitro and cellular assays.
  • In vivo: n/a

 

 

Reference:

  • 1. Choi YJ, et al. Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion. (2012) PLoS One. 7(8):e43418. 

 

 


Products are for research use only. Not for human use.

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