IDH2-C100, IHD2 Inhibitor


Catalog No. size PriceQuantity
M60190-2S 2mg solid $134
M60190-10S 10 mg solid $530

Description

IDH2-C100 is a potent and selective inhibitor of IDH2 R140Q and R172K mutant first reported in patent WO 2013102431. It can inhibit the enzymatic activity of IDH2 R140Q and R172K in vitro with an IC50 < 0.1 µM. It has IC50 < 0.1 µM in U87MG pLVX-IDH2 R140Q-neo cell based assay. It is an analog of clinical IDH2 inhibitor AG-221 by Thomson Reuters Integrity analysis.

Product information

CAS Number: 1446506-78-0

Molecular Weight: 305.38

Formula: C18H19N5

Chemical Name: N2-isopropyl-N4,6-diphenyl-1,3,5-triazine-2,4-diamine

Smiles: CC(C)NC1=NC(NC2C=CC=CC=2)=NC(=N1)C1C=CC=CC=1

InChiKey: WVHMNCOFPWFUMF-UHFFFAOYSA-N

InChi: InChI=1S/C18H19N5/c1-13(2)19-17-21-16(14-9-5-3-6-10-14)22-18(23-17)20-15-11-7-4-8-12-15/h3-13H,1-2H3,(H2,19,20,21,22,23)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 50 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

IDH2-C100 was used at 1-5 µM in vitro and cellular assays.

References:

  1. Giovanni Cianchetta, et al. Therapeutically active compounds and their methods of use. (2013) PCT WO 2013102431

Products are for research use only. Not for human use.

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