IDH2-C100 is a potent and selective inhibitor of IDH2 R140Q and R172K mutant first reported in patent WO 2013102431. It can inhibit the enzymatic activity of IDH2 R140Q and R172K in vitro with an IC50 < 0.1 µM. It has IC50 < 0.1 µM in U87MG pLVX-IDH2 R140Q-neo cell based assay. It is an analog of clinical IDH2 inhibitor AG-221 by Thomson Reuters Integrity analysis.
CAS Number: 1446506-78-0
Molecular Weight: 305.38
Chemical Name: N2-isopropyl-N4,6-diphenyl-1,3,5-triazine-2,4-diamine
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 50 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
IDH2-C100 was used at 1-5 µM in vitro and cellular assays.
- Giovanni Cianchetta, et al. Therapeutically active compounds and their methods of use. (2013) PCT WO 2013102431
Products are for research use only. Not for human use.
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