TCID, Ubiquitin C-terminal Hydrolase-L3 (UCH-L3) Inhibitor


Catalog No. size PriceQuantity
M60197-2S 2 mg solid $99
M60197-10S 10mg solid $391

Description

Product Information
Molecular Weight: 283.92
Formula: C9H2Cl4O2
Purity: ≥98%
CAS#: 30675-13-9
Solubility: DMSO up to 50 mM
Chemical Name: 4,5,6,7-Tetrachloro-1H-Indene-1,3(2H)-dione
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

 

TCID is a novel potent and selective inhibitor of ubiquitin C-terminal hydrolase-L3 (UCH-L3) with an IC50 ~0.6 μM. It has ~125-fold greater selectivity over UCH-L1 (ubiquitin C-terminal hydrolase L1, IC50 ~75 μM). TCID can diminish glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons.

 


How to Use:

 

 

  • In vitro: TCID was used at 10-30 µM final concentration in various in vitro assays.
  • In vivo: n/a

 

 

 


Reference:

 

  1. Liu Y, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. (2003) Chem Biol. 10(9):837-46.
  2. de Juan-Sanz J, et al. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. (2013) PLoS One. 8(3):e58863.

 

 


Products are for research use only. Not for human use.

Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed