Y-320---IL-17 Immunomodulator


Catalog No. size PriceQuantity
M60200-2S 2mg solid $89
M60200-10S 10mg solid $365

Description

Product Information
Molecular Weight: 505.01
Formula: C27H29ClN6O2
Purity: ≥98%
CAS#: 288250-47-5
Solubility: DMSO up to 20 mM
Chemical Name: 1-(4-chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

Y-320 is an orally active potent immunomodulator. It inhibits IL-15-induced IL-17 production by CD4 T cells with an IC50 of 20 nM. Therapeutic treatment with Y-320 (0.3 to 3 mg/kg orally) significantly inhibited the progression of arthritis and joint destruction in type II collagen-induced arthritis (CIA) in DBA/1J mice. Y-320 inhibited the elevation of IL-17 mRNA expression in the joint of CIA mice. Concomitant treatment with Y-320 and anti-mouse TNF-alpha antibody showed a synergistic effect in mouse CIA. Moreover, therapeutic treatment with Y-320 (0.3 and 1 mg/kg orally) ameliorated CIA in cynomolgus monkeys.

 

How to Use:

 

  • In vitro:  Y-320 was used at 0.1-1 µM final concentration in various in vitro assays.
  • In vivo:  Y-320 was administered orally at 0.3-3 mg/kg once day in mouse models.

 

 

Reference:

  1. Ushio H, et al. A New Phenylpyrazoleanilide, Y-320, Inhibits Interleukin 17 Production and Ameliorates Collagen-Induced Arthritis in Mice and Cynomolgus Monkeys. (2013)  Pharmaceuticals (Basel) 7(1), 1-17.


 

Products are for research use only. Not for human use.

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