Y-320, IL-17 Immunomodulator.


Catalog No. size PriceQuantity
M60200-2S 2mg solid $89
M60200-10S 10mg solid $365

Description

Y-320 is an orally active potent immunomodulator. Y-320 inhibits IL-15-induced IL-17 production by CD4 T cells with an IC50 of 20 nM. Therapeutic treatment with Y-320 (0.3 to 3 mg/kg orally) significantly inhibited the progression of arthritis and joint destruction in type II collagen-induced arthritis (CIA) in DBA/1J mice. Y-320 inhibited the elevation of IL-17 mRNA expression in the joint of CIA mice. Concomitant treatment with Y-320 and anti-mouse TNF-alpha antibody showed a synergistic effect in mouse CIA. Moreover, therapeutic treatment with Y-320 (0.3 and 1 mg/kg orally) ameliorated CIA in cynomolgus monkeys.

Product information

CAS Number: 288250-47-5

Molecular Weight: 505.01

Formula: C27H29ClN6O2

Chemical Name: 1-(4-chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide

Smiles: CC1=C(C=NN1C1C=CC(Cl)=CC=1)C(=O)NC1=CC(C#N)=C(C=C1)N1CCC(CC1)N1CCOCC1

InChiKey: BWZNJVZTAWBIFG-UHFFFAOYSA-N

InChi: InChI=1S/C27H29ClN6O2/c1-19-25(18-30-34(19)24-5-2-21(28)3-6-24)27(35)31-22-4-7-26(20(16-22)17-29)33-10-8-23(9-11-33)32-12-14-36-15-13-32/h2-7,16,18,23H,8-15H2,1H3,(H,31,35)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: (25°C) DMSO: 11 mg/mL(21.78 mM). Water: Insoluble.

Shipping Condition: Shipped under ambien...

Storage Condition: Dry, dark and -20 oC...

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Y-320 was used at 0.1-1 µM final concentration in various in vitro assays.

In Vivo:

Y-320 was administered orally at 0.3-3 mg/kg once day in mouse models.

References:

  1. Ushio H, et al. A New Phenylpyrazoleanilide, Y-320, Inhibits Interleukin 17 Production and Ameliorates Collagen-Induced Arthritis in Mice and Cynomolgus Monkeys. (2013) Pharmaceuticals (Basel) 7(1), 1-17.

Products are for research use only. Not for human use.

Payment & Security

American Express Diners Club Discover JCB Mastercard PayPal Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed