WAY-316606, Secreted Frizzled-related Protein-1 (sFRP-1) Inhibitor


Catalog No. size PriceQuantity
M60215-2S 2 mg solid $139
M60215-10S 10mg solid $556

Description

Product Information
Molecular Weight: 484.94
Formula: C18H19F3N2O4S2.HCl
Purity: ≥98%
Relate CAS#:   915759-45-4 (free base)
CAS#: 1781835-02-6
Solubility: DMSO up to 100 mM
Chemical Name: 5-(Phenylsulfonyl)-N-4-piperidinyl-2-(trifluoromethyl)benzene sulfonamide hydrochloride
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

 

Biological Activity:

WAY-316606 is a novel potent and selective inhibitor of secreted frizzled-related protein-1 (sFRP-1) with an IC50 ~ 0.65 μM. It prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. WAY-316606 can increase total bone area in a murine calvarial organ culture assay.

 

How to Use:

 

  • In vitro:  WAY-316606 was used at 1-10 µM final concentration in various in vitro assays.
  • In vivo:  n/a

 

 

Reference:

  • 1. Bodine PV, et al. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. (2009) Bone. 44(6):1063-8.
  • 2. Moore WJ, et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. (2009) J Med Chem. 52(1):105-16.
  • 3. Moore WJ, et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. (2010) Bioorg Med Chem. 18(1):190-201.

 

 


Products are for research use only. Not for human use. 

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