|Relate CAS#:||915759-45-4 (free base)|
|Solubility:||DMSO up to 100 mM|
|Chemical Name:||5-(Phenylsulfonyl)-N-4-piperidinyl-2-(trifluoromethyl)benzene sulfonamide hydrochloride|
|Storage:||Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.|
WAY-316606 is a novel potent and selective inhibitor of secreted frizzled-related protein-1 (sFRP-1) with an IC50 ~ 0.65 μM. It prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. WAY-316606 can increase total bone area in a murine calvarial organ culture assay.
How to Use:
- In vitro: WAY-316606 was used at 1-10 µM final concentration in various in vitro assays.
- In vivo: n/a
- 1. Bodine PV, et al. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. (2009) Bone. 44(6):1063-8.
- 2. Moore WJ, et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. (2009) J Med Chem. 52(1):105-16.
- 3. Moore WJ, et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II. (2010) Bioorg Med Chem. 18(1):190-201.
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