Description
Product Information
| Molecular Weight: | 440.31 |
| Formula: | C17H18BrN3O4S |
| Purity: | ≥98% |
| CAS#: | 919973-83-4 |
| Solubility: | DMSO up to 20 mM |
| Chemical Name: | 4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide |
| Storage: | Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year. |
Biological Activity:
OF-1 is the potent and selective BRPF (BRomodomain and PHD Finger containing) inhibitor. It binds to BRPF1B with a KD of 100 nM (ITC), to BRPF2 with a KD of 500 nM (ITC) and to BRPF3 with a KD of 2.4 mM (ITC). It has general >100-fold selectivity against other bromodomains (39-fold selectivity over BRD4). OF-1 increases thermal stability in the cellular thermal shift assay (CETSA) of full length BRPF1B at 1 µM and also demonstrates accelerated FRAP recovery at 5 µM in the BRPF2 FRAP assay. It shows modest general cytotoxicity.
How to Use:
- In vitro: OF-1 was used at 5-10 µM final concentration in various in vitro assays.
- In vivo: n/a
Reference
- http://www.thesgc.org/chemical-probes/OF-1
ProProducts are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.