UM171, Human HSC Self-renewal Agonist

Catalog No. Size PriceQuantity
M60223-2S 2 mg solid $159Unavailable


Product Information
Molecular Weight: 526.46
Formula: C25H27N9. 2HCI
Purity: ≥98%
CAS#: 1448724-09-1
Solubility: DMSO up to 100 mM
Chemical Name: (1r,4r)-N1-(2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine hydrochloride
Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.


Biological Activity:



UM171 is a potent small molecule that stimulates the ex vivo expansion of human hematopoietic stem cells/HSC capable of reconstituting human hematopoiesis for at least 6 months in immunocompromised mice. It attenuates cell differentiation and promotes ex vivo expansion of long-term human HSC (LT-HSC) at 35 nM in 11 days fed-batch cultures. UM171’s mechanism is independent of suppression of the aryl hydrocarbon receptor (AHR) like SR1. The properties of UM171 make it a potential candidate for hematopoietic stem cell transplantation and gene therapy.

How to Use:



In vitro:  For transplantation experiments, the fed-batch culture system was used. 1x105 CD34+ cord blood (CB) cells/ml were injected into 12 ml or 25 ml bags connected to a syringe loaded pumping system and maintained on an orbital shaker at 37°C and 5% CO2 in air. The pump was set to continuously deliver HSC expansion media supplemented with UM171 (35 nM) at a flow rate of 0.7 μl/min. 

In vivo: NSG mice were injected with CD34+ CB cells that had been originally cultured in UM171.



  1. Fares I, et al. Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal. (2014) Science. 345(6203):1509-12. 

Products are for research use only. Not for human use.

Payment & Security

American Express Apple Pay Diners Club Discover Elo Google Pay JCB Mastercard PayPal Shop Pay Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

You may also like

Recently viewed